Welcome!
The Cardiovascular Physiology and Surgery Core is available to provide the Johns Hopkins community and beyond three types of cardiovascular procedures on small animals, including, but not limited to, mouse and rat: echocardiography, survival surgery, and hemodynamics. Other procedures may be possible after discussion with the core surgeons. Within each of these three areas, there are several different specific techniques and procedures that will be offered. Echocardiograpy: Functional assessment of the heart and major blood vessels is provided by this service. Images are generated using our state-of-the-art Visual-Sonics 2100 imaging system. This machine provides high resolution imaging and also has tissue Doppler capabilities, including speckle tracking for regional strain analysis. Functional imaging is also available to assess aortic diameter and wall thickening, flow in the aorta to assess vascular stiffening (pulse wave velocity, velocity time integral used to determine cardiac output, etc.). Survival Surgery: We provide a variety of surgically generated heart disease models for use in mice or rats. This includes aortic or pulmonary artery banding for pressure-overload, myocardial infarction or ischemic reperfusion models of the left ventricle, and osmotic pump implantation for delivery of pharmaceuticals. Pressure-Volume Loops: Analysis of right or left heart function is possible by inserting a miniature pressure-volume catheter into the relevant ventricle to measure in situ cardiac function using pressure-volume relationships. This is used to assess ventricular pressures, systolic and diastolic function, relaxation rates, filling rates, load-independent contractility paramenters, disatolic compliance, and other indexes. These studies are not designed to be survival surgeries.
We wouldl like to welcome Erhe Gao, MD to our core. He brings with him many years of experience doing small animal surgery. He will be joining us on a limited basis, once or twice a month, to do most of the more complicated surgical procedures we offer.
David Kass, Professor Program Chairman
410-955-7153
dkass@jhmi.edu
Nadan Wang, Lab Manager/Director
410-502-2044
nwang31@jhmi.edu
Michelle "Missy" Leppo, Surgical Technician
410-955-3814
mleppo@jhmi.edu
Erhe Gao, Surgeon
erhe.gao@temple.edu
Location and hours of operation
|
Nadan Missy Erhe occasionally, 9am - 5pm |
720 Rutland Avenue. Baltimore, MD 21205 720 Rutland Avenue, Baltimore, MD 21205 720 Rutland Avenue. Baltimore, MD 21205 |
Links and Resources
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| David Kass |
Program Chairman
|
410-955-7153
|
dkass@jhmi.edu
|
Ross 858
|
| Nadan Wang |
Director
|
410-502-2044
|
nwang31@jhmi.edu
|
Ross 868
|
| Michelle "Missy" Leppo |
Surgical Technician
|
410-955-3814
|
mleppo@jhmi.edu
|
Ross 812
|
| Erhe Gao |
Surgeon
|
erhe.gao@temple.edu
|
Ross 868
|
| Service list |
| ► Echocardiography and Ultrasound Imaging (1) | |||
| Name | Description | Price | |
|---|---|---|---|
| Fetal Mouse Imaging (per embryo) |
Echocardiography for mouse enbryo LV Manual data analysis only |
Inquire | |
