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Phenocore, Phenotyping and Pathology Core

Overview of Services

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Mission: The Phenotyping Core promotes functional genomics and other preclinical translational science at Johns Hopkins, by assisting and collaborating in the characterization and use of genetically and phenotypically relevant animal models of disease and gene function, by:

  1. Preclinical research pathology support and collaboration, including anatomic pathology (macroscopic dysmorphology and histopathology), and clinical pathology.
  2. Training and education in animal model pathobiology, evaluation techniques, phenotyping strategies, especially for genetically engineered mice (GEM).



Services/collaborations include:

●               Anatomic Pathology (Preclinical, pre GLP, GLP);

●               Clinical Pathology (Preclinical hematology (CBC), Clinical Chemistry, urinalysis);

●               Body Composition by QNMR (EchoMRITM-100);

●               Faxitron® high resolution radiography;

●               Specimen Photography, macrophotography, photomicroscopy, morphometry;

●               Training in procedures, techniques.



Note: Grant supported (%FTE) collaborations should be developed for large and long term projects involving pathology. 

Pathology support and collaboration frequently involve acquisition, analysis and interpretation of data, as well as contributions to study design, images and manuscript preparation that warrant authorship. Johns Hopkins Policy on authorship should be followed, per: http://www.hopkinsmedicine.org/som/faculty/policies/facultypolicies/responsible_conduct.html   

 

 

Leadership

Cory Brayton, DVM - Director Phenotyping Core
Diplomate, ACLAM, ACVP
Phone: 410-502-3050
Email: cbrayton@jhmi.edu **

 

Nadine Forbes-McBean, MS - Research Specialist/Lab Manager Phenotyping Core
Phone: 443-287-0917
Email: nforbes1@jhmi.edu

 

Wendy Elza - Administrative Executive Phenotyping Core
Phone: 410-502-3050
Email: welza1@jhmi.edu

 

** Email cbrayton@jhmi.edu if you do not receive a prompt response to telephone enquiries.
 

Location and hours of operation

Hours Location

Monday - Friday 9:00am - 5:00pm  


733 North Broadway
Miller Research Building; Office 851
Baltimore, Maryland 21205 

 

Office Phone: 410-502-3050

Links and Resources

  1. Johns Hopkins Phenotyping (and Preclinical Pathology) Core (Additional resources, laboratory manual, course information)
  2. Behavioral Core at the School of Medicine (Neurobehavioral Phenotyping MRB/BRB)
  3. Johns Hopkins Ocology Tissue Services (TMA, Digital Imaging and Immunohistochemistry)
  4. Centralized Service for Metabolism Research (CSMR - Metabolic Phenotyping)
  5. Center for Resources in Integrative Biology (CRIB - Metabolomics, Mass Spectrophotometry etc)
  6. Small Animal Imaging Resource Program (SAIRP – Imaging MRB/BRB)
  7. Transgenic Core Johns Hopkins (targeted mutations, transgenesis, rederivation)

Contacts

Name Role Phone Email Location
Cory Brayton, DVM
Director
 
410-502-3050**
 
cbrayton@jhmi.edu
 
Miller Research Building; Suite 851
 
Nadine Forbes-McBean, MS
Phenotyping Core Research Technician
 
(410) 502-3050
 
nforbes1@jhmi.edu
 
Miller Research Building; Suite 852
 
Wendy Elza, BA
Administrative Executive Phenotyping Core
 
410-502-3050
 
welza1@jhmi.edu
 
Miller Research Building; Suite 851
 

Services

Name Description
Faxitron   
Faxitron (film)   
QNMR Imaging   
Clinical Chemistry: by Individual Tests   
Comprehensive Necropsy (mice) 10 slide w/ report 

Includes blood collection, CBC, gross examination, dissection, tissue collection and trimming, fixation, decalcification, histology examination of 40 tissues, and report.
Histology processing is charged separately (see below).

 
Clinical Chemistry: Custom Panel 12-17 tets   
Custom Necropsy 

From $75.00/hr depending on species and procedures.

 
Clinical Chemistry: Custom Panel 4-5 tests   
Gross only necropsy and report 

Mice or rats only. For other species, use custom necropsy option.

 
Clinical Chemistry: Custom Panel 6-11 tests   
Pathology Consultation/Collaboration 

Lesser cost of $20./slide or $200./hr.

Initial discussion/consultation (<1hr) is not charged.

 
Clinical Chemistry: Electrolyte panel   
Small Animal Perfusion   
Blood/Specimen Collection 

Lesser cost of $10.00/animal or $75.00/hr.

 
Clinical Chemistry: Kidney LongPanel   
Clinical Chemistry: Kidney Short Panel   
Histology Processing, Special Stains, Scanning 

Prices vary for processing of trimmed tissues in cassettes to paraffin blocks, then stained sections on glass slides, as well as for special stains, special processing or digital slide scanning. We will assist in pricing and selecting options for your projects.

 
Clinical Chemistry: Lipid panel   
Clinical Chemistry: Liver Long Panel   
Clinical Chemistry: Liver Short Panel   
Clinical Chemistry: Metabolic Panel   
Clinical Chemistry: Mini Screen   
Clinical Chemistry: Serum/Plasma isolation   
Clinical Chemistry: Super Chem Panel   
Cytology: Cell count by Hemocytometer   
Cytology: Cytospin   
Fecal occult blood    
Glucometry: Cage Side   
Glucometry: In Lab   
Glucometry: Investigator Use   
Hematology: Automated blood cell count (CBC)   
Hematology: Automated blood cell count (CBC) plus stained smear   
Hematology/Cytology: Hema3 cell staining   
Hematology/Cytology: Manual Differential   
Hematology: Survival Bleed   
Hematology: Terminal blood collection   
Urinalysis: Dipstick   
Urinalysis: Sediment analysis   
Urinalysis: Specific Gravity   
Urinalysis: Urine Chemistry   

Service list


Search available services: View: by category alphabetically
Anatomic Pathology (7)
Clinical Pathology (30)
Imaging (3)