High Throughput Screening (ChemCORE)

High Throughput Screening Services

As a screening center for the NIH Molecular Libraries Probe Centers Network (MLPCN), Johns Hopkins ChemCORE is a well established high throughput screening facility which has carried out 100+ projects for drug discovery community in the past 15 years.

ChemCORE provides a variety of services and expertise with automation and detection capabilities to make drug discovery process streamlined and fast:

  • Screening with in house large libraries:
    - NIH full collection (300,000 compounds) 
    - ChemBridge Diverse Set (50,000), ChemBridge CNS Set (50,000 compounds) 
    - Newly arrived ChemDiv Diverse Set (100,000) and its repicked cost-saving set (10,000 compounds)
    - Newly replenished and expanded Johns Hopkins Drug Library - JHDLv3 (4,500 drugs)
  • Screening with FDA approved drug collection for possible repurposing/repositioning
  • Pilot or proof of concept screening with special smaller libraries: MicroSource Spectrum (2,000) and Sigma LOPAC(1,280)
  • Assay development and implementation: cell based and protein based assays, on 96/384/1536 well format
  • Automating many processes other than compound screening: RNA-Seq, MODLI-TOF, large scale sample preparation and reformatting
  • Support letter for grant application
  • Equipment user training

Advanced Instruments

  • Tecan Safire²™ multimode microplate reader: luminescence, florescence, polarization.
  • Molecular Devices SpectraMax i3X multimode plate reader, with online reagent dispensing
  • BD Pathway™ 855 Bioimager: high speed automated cell imaging
  • FDSS6000 and FDSS7000 System: florescence/luminescence kinetic reading
  • Epic ™ System: label-free detection on 384-well format
  • Liquid handling automation, more than 5 workstations for wide range of volume for 96/384/1536-well plates
  • Echo 650 acoustic dispenser, non-contact, as low as 2.5nL



Jun Liu on Looking to Nature for New Medications



Jun Liu, PI



Alan Long, Manager






Sr. Research Engineer



Location and hours of operation

Hours Location

Monday - Friday  

9am - 5pm

Miller Research Building 346

733 North Broadway, Baltimore, Maryland 21205

Links and Resources

  1. ChemCORE Facility


Name Role Phone Email Location
Alan Long, MS
Lab Manager
MRB 349
Jun Liu
Hunterian 516