As a screening center for the NIH Molecular Libraries Probe Centers Network (MLPCN), Johns Hopkins ChemCORE is a well established high throughput screening facility which has carried out 100+ projects for drug discovery community.
ChemCORE provides a variety of services and expertise with automation and detection capabilities to make drug discovery process streamlined and fast:
Screening with in house large libraries: NIH collection (300,000 compounds), ChemBridge Diverse Set (50,000), CNS Set (50,000)
Screening with FDA approved drug collection for possible repurposing/repositioning
Pilot or proof of concept screening with special smaller libraries: MicroSource Spectrum (2,000) and Sigma LOPAC(1,280)
High throughput ion channel test: special expertise with membrane protein targets
Assay development and implementation: cell based and protein based assays, on 96/384/1536 well format
Automating many processes other than compound screening: RNA-Seq, MODLI-TOF, large scale sample preparation and reformatting